Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions
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چکیده
منابع مشابه
ChemInform Abstract: Direct Synthesis of β- Hydroxy-α-amino Acids via Diastereoselective Decarboxylative Aldol..
A straightforward metal-free synthesis of anti-β-hydroxy-r-amino acids is described. The organic base-mediated decarboxylative aldol reaction of cheap, readily available r-amidohemimalonates with various aldehydes afforded under very mild conditions anti-β-hydroxy-r-amido esters in high yields and complete diastereoselectivity. Simple one-pot subsequent transformations enabled the corresponding...
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2011
ISSN: 0040-4020
DOI: 10.1016/j.tet.2011.06.043